Meig’s Syndrome with Elevated CA 125: Case Report with a Journey through Literature

The occurrence of pleural effusion associated with ascites and an ovarian fibroma or fibro thecoma was first described as a clinical syndrome by Meigs and Cass in 1937 [1-3]. Elevated serum carbohydrate antigen 125 (CA 125) leves in postmenopausal women with solid adnexal masses, ascites and pleural effusion are highly suggestive for malignant ovarian tumor [1-4]. A minority of these patients has a benign condition known as Meigs’ syndrome; therefore it is mandatory surgery and histological confirmation of the preoperative diagnosis [2]. Clinicians should be aware of this clinical entity because of its benignity and differential diagnosis with malignant ovarian tumors that can be similar at presentation but have a different treatment and prognosis [5-8].